![]() Skin testing can confirm the sensitization. In at least half of the patients there is a history of previous use of protamine, either in a similar situation or as protamine zinc insulin. 155 It is frequently associated with an anaphylactic reaction and bronchospasm, an increase in pulmonary artery pressure with normal wedge pressure, and hypotension. However, there have been a number of cases of noncardiogenic pulmonary edema within minutes to 1 or 2 hours after the administration of the drug. Systemic hypotension is not uncommon following administration of this drug. Protamine sulfate is used to reverse the anticoagulant effects of heparin following cardiovascular surgical procedures. Limper MD, in Murray and Nadel's Textbook of Respiratory Medicine (Sixth Edition), 2016 Protamine While the cell viability decreased dramatically from 80% to 20% in the presence of DOX–PICs. The PICs efficiently associated DNA with above 80% viability of HEK293T cells and HeLa cells against PICs showing the much lower cytotoxicity of PICs when compared with that of 25 kDa polyethyleneimine (PEI). Then, DOX–PASP solution was then added into PS/DNA solution to form PICs (lower than 210 nm Cheng et al., 2009). Dox was covalently conjugated to PASP via CDI coupling reaction whereas PS forms ionic complex with DNA. (2009), polyionic complexes (PICs) were prepared based on the ionic interaction between the polycation PS and the polyanion poly( l-aspartic acid) (PASP) for combined delivery of the anticancer drug, Dox, and plasmid DNA delivery. Protamine sulfate (PS), mainly composed of poly( l-arginine), is biodegradable and has been widely used for biomedical and biotechnological applications. Kamel, in Advances in Protein Chemistry and Structural Biology, 2015 3.8 Protamine Use: Low-dose regimen for prevention of postoperative deep venous thrombosis and pulmonary embolism in patients greater than 40 years old undergoing major abdominothoracic surgery or who, for other reasons, are at risk of developing thromboembolic disease.Ahmed O. Use: Low-dose regimen for prevention of postoperative deep venous thrombosis and pulmonary embolism in patients greater than 40 years old undergoing major abdominothoracic surgery or who, for other reasons, are at risk of developing thromboembolic disease. Usual Adult Dose for Prevention of Thromboembolism in Atrial Fibrillation ![]() ![]() Usual Adult Dose for Deep Vein Thrombosis - Prophylaxis Administer by deep subcutaneous (intrafat, e.g., above the iliac crest or abdominal fat layer, arm, or thigh) injection with a fine (25 to 26 gauge) needle to minimize tissue trauma.Prophylaxis and treatment of peripheral arterial embolism.ĥ000 units subcutaneously 2 hours before surgery and 5000 units subcutaneously every 8 to 12 hours thereafter for 7 days or until the patient is ambulatory, whichever is longer.Treatment of acute and chronic consumption coagulopathies (disseminated intravascular coagulation).Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation.Prophylaxis and treatment of venous thrombosis and pulmonary embolism.Dosage and administration must be individualized according to the results of suitable laboratory tests.Consult the latest guidelines regarding duration and intensity of anticoagulation for the indicated conditions.Recommended doses are based on a 68 kg patient.Maintenance dose: 5000 to 10,000 units IV every 4 to 6 hoursģ33 units/kg subcutaneously followed by 250 units/kg subcutaneously every 12 hours the following dosage regimen has also been recommended: 5000 units by IV injection followed by 10,000 to 20,000 units subcutaneously, and then 8000 to 10,000 units subcutaneously every 8 hours or 15,000 to 20,000 units subcutaneously every 12 hours.Maintenance dose: 20,000 to 40,000 units per 24 hours by continuous IV infusion.Initial dose: 5000 units by IV injection.The manufacturer provides the following dosing guidelines based on clinical experience: Usual Adult Dose for Deep Vein Thrombosis Patency Maintenance of Indwelling Intravenous Devices.Prevention of Thromboembolism in Atrial Fibrillation.
0 Comments
Leave a Reply. |